Updates on the latest news and insights from Esperante and its portfolio.

Medicenna Announces Promising Single-Agent Response and Durability of MDNA11 in the Phase 1/2 ABILITY Study During Dose Escalation at the 38th Annual Meeting of the Society for Immunotherapy of Cancer (SITC)


6 November 2023

Medicenna Therapeutics Corp. (“Medicenna” or the “Company”) (TSX: MDNA), a clinical-stage immunotherapy company focused on the development of Superkines, today announced that new clinical data from the Phase 1 monotherapy dose escalation/evaluation portion of the Phase 1/2 ABILITY-1 (A Beta-only IL-2 ImmunoTherapY) study evaluating MDNA11, the only long-acting, ‘beta-enhanced not-alpha’ interleukin-2 (IL-2) super-agonist in clinical development, in patients with advanced solid tumors, were presented at the 38th Annual Meeting of the Society for Immunotherapy of Cancer (SITC) held in San Diego, CA, on November 4th, 2023.

“We are very encouraged by two partial responses and three durable stable diseases in patients with advanced cancer who had progressed on multiple prior therapies, reinforcing MDNA11’s promising single-agent activity,” said Fahar Merchant, Ph.D., President and Chief Executive Officer of Medicenna. “These data add to the growing body of evidence demonstrating the clinical effectiveness of MDNA11 with highly favorable underlying immune response characterized by robust expansion and activation of CD8+ T cells with minimal impact on immune-suppressive Tregs. MDNA11 with uniquely differentiating ‘beta-enhanced not-alpha’ features, continues to be a potential best-in-class next-generation IL-2 super-agonist for treatment of advanced solid tumors. We look forward to reporting results from the monotherapy expansion and combination escalation arms of the Phase 2 study in the first half of 2024.”

Read full press release here